Patients with cardiac RyR defects had general anesthesia without complications.

2004 OCT 4 - (NewsRx.com & NewsRx.net) -- A recent report describes the use of volatile anesthetics and succinylcholine in patients with cardiac ryanodine receptor defects.

According to the report from Finland, "Familial polymorphic (catecholaminergic) ventricular tachycardia is an arrhythmogenic cardiac disorder caused by mutations of the myocardial isoform of the ryanodine receptor gene (RyR2). Mutations of the corresponding gene in the skeletal muscle (RyR1) predispose its carriers to malignant hyperthermia upon use of volatile anesthetics or succinylcholine, which further deteriorate the inherited intracellular calcium release disorder."

H. Swan and …